Position overviewPosition title: Stem Cell Specialist (Assistant Specialist - Associate Specialist ranks)
Open date: April 1st, 2021
Last review date: Monday, May 3, 2021 at 11:59pm (Pacific Time)
Applications received after this date will be reviewed by the search committee if the position has not yet been filled.
Final date: Wednesday, Dec 22, 2021 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.
The UC Santa Cruz Genomics Institute Organized Research Unit, at the University of California, Santa Cruz (UCSC) invites applications for the position of Stem Cell Models Research Specialist in the Salama/Haussler laboratory. Under the direction of Dr. Sofie Salama, the research specialist will support and contribute to research that uses human and non-human primate pluripotent stem cells and high throughput sequencing assays to understand the evolution and function of genomic innovations that drive new gene regulatory programs and human brain development. This work will involve using genetic engineering to generate pluripotent stem cell lines that allow CRISPR/Cas9 based overexpression or knockdown screens, or enable expression of fluorescent reporters, optogenetic actuators or calcium sensors in a cell-type specific manner. Engineered cell lines will be used for generating pluripotent stem cell derived cerebral cortex organoids for phenotypic characterization using immunohistochemistry and high throughput sequencing-based measurements. The candidate will also make scholarly contributions to the research program through reading primary literature, participate in the preparation and/or editing scientific manuscripts and regular lab meeting presentations. In addition to supporting and contributing to research, the incumbent will support our UCSC-UCSF braingeneers project with lab operations support including assisting with ordering, reimbursement and spending reports, maintaining inventories, scheduling meetings, and communications. The candidate will be expected to learn new techniques and implement protocols, have strong attention to detail, strong written and verbal communication skills, exercise good time management and problem-solving skills, and work effectively in a team environment.
Applicants with expertise in any of the following areas are strongly encouraged to apply: pluripotent stem cell culture, CRISPR/Cas9-based genetic engineering, cerebral cortex organoid culture and analysis including histology analysis of tissue sections, and/or high throughput sequencing-based gene expression analysis.
Genomics Institute: https://ucscgenomics.soe.ucsc.edu/
Bachelor’s degree (or equivalent foreign degree) in biology, molecular biology, biochemistry.
At least two years of biological wet lab experience including mammalian cell culture and molecular biology experiments after obtaining a Bachelor’s or equivalent foreign degree.
Curriculum Vitae - Your most recently updated C.V.
Cover Letter - Letter that summarizes in detail your qualifications and interest in the position and your experience in the following areas:
a. With CRISPR/Cal9 gene editing
b. With pluripotent stem cell culture and differentiation.
c. With high throughput sequencing.
d. Supporting lab operations (ordering, budgets, chemical inventory, hazardous waste disposal and related functions)
- 3 letters of reference required
Note that your references, or dossier service, will submit their confidential letters directly to the UC Recruit System.
All letters will be treated as confidential per University of California policy and California state law. For any reference letter provided via a third party (i.e., dossier service, career center), direct the author to UCSC’s confidentiality statement at http://apo.ucsc.edu/confstm.htm.
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