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Structural Biology IT Specialist

Position overview

Position title: Structural Biology IT Specialist (Associate Specialist - Specialist ranks)
Salary range: Commensurate with qualifications and experience. A reasonable estimate for this position is $70,500 - $86, 900.
Percent time: Full-time (100%)
Anticipated start: As soon as possible after the initial review of applications.
Position duration: Initial appointment will be for two years, with the possibility of reappointment. Should the hiring unit propose reappointment; a review to assess performance will be conducted. Reappointment is also contingent upon the availability of funding.

Application Window

Open date: March 21, 2024

Next review date: Monday, Apr 22, 2024 at 11:59pm (Pacific Time)
Apply by this date to ensure full consideration by the committee.

Final date: Friday, Mar 21, 2025 at 11:59pm (Pacific Time)
Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.

Position description

Professor Seth Rubin in the Department of Chemistry and Biochemistry at the University of California, Santa Cruz (UCSC) invites applications for a Structural Biology IT Specialist. The specialist will contribute to structural biology research projects in collaboration with researchers in the Division of Physical and Biological Sciences and manage data processing and storage in the electron microscopy facility.

Primary responsibilities will include overseeing and maintaining computational resources for electron microscopy and structural biology research. The successful candidate will also participate in collaborative research towards macromolecular structure determination and modelling with faculty research groups and train students and postdoctoral fellows in structural biology computational methods. The incumbent’s role will be primarily on the end of data processing and structure solving using available electron microscopy and deep learning software packages, and they will train others to perform these tasks.

Applicants with experience in the following areas are strongly encouraged to apply:

  • Knowledge of processing data from electron diffraction and eletron tomography experiments.
  • Knowledge of implementing deep learning tools for structural modeling such as AlphaFold and Multimers.

The successful candidate may be eligible for remote or hybrid work arrangements.

Department of Chemistry and Biochemistry:

UCSC Biomolecular Cryo-EM Facility:


Basic qualifications (required at time of application)
  • Master’s degree or higher (or an equivalent foreign degree) in chemistry, biochemistry, molecular biology, physics, computer science, or a related field.
  • Knowledge of macromolecular structure determination by single particle analysis of cryo-electron microscopy data.
  • Experience in management of large data sets.
  • Knowledge of, and experience with troubleshooting software used for structural biology research, including experimental and deep learning approaches.
  • Demonstrated record of working with and training a diverse group of students, postdoctoral fellows, and scientists.

Application Requirements

Document requirements
  • Curriculum Vitae - Your most recently updated C.V., which must include a list of publications (if any). Please include DOI links or the URLs of PDFs for any publications listed on your CV.

  • Cover Letter - Letter of application that briefly summarizes your qualifications and interest in the position.

Reference requirements
  • 3 required (contact information only)

Applicants must provide the names and contact information of their references. The hiring unit will request confidential letters* from the references of those applicants who are under serious consideration. Note that your references, or dossier service, will submit their confidential letters directly to the UC Recruit System.

*All letters will be treated as confidential per University of California policy and California state law. For any reference letter provided via a third party (i.e., dossier service, career center), direct the author to UCSC’s confidentiality statement at

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About UC Santa Cruz

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. UC Santa Cruz is committed to excellence through diversity and strives to establish a climate that welcomes, celebrates, and promotes respect for the contributions of all students and employees. Inquiries regarding the University’s equal employment opportunity policies may be directed to the Office for Diversity, Equity, and Inclusion at the University of California, Santa Cruz, CA 95064 or by phone at (831) 459-2686.

Under Federal law, the University of California may employ only individuals who are legally able to work in the United States as established by providing documents as specified in the Immigration Reform and Control Act of 1986. Certain UCSC positions funded by federal contracts or sub-contracts require the selected candidate to pass an E-Verify check (see The university sponsors employment-based visas for nonresidents who are offered academic appointments at UC Santa Cruz (see

UCSC is a smoke & tobacco-free campus.

If you need accommodation due to a disability, please contact Disability Management Services at (831) 459-4602.

UCSC is committed to addressing the spousal and partner employment needs of our candidates and employees. As part of this commitment, our institution is a member of the Northern California Higher Education Recruitment Consortium (NorCal HERC). Visit the NorCal HERC website at to search for open positions within a commutable distance of our institution.

The University of California offers a competitive benefits package and a number of programs to support employee work/life balance. For information about employee benefits please visit

As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

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Job location

Santa Cruz, California. The selected candidate may be eligible for remote or hybrid work arrangements.